Non-Surgical Periodontal Therapy Improves Clinical Outcomes in Patients with Chronic Periodontitis Independent of the Use of Nigella Sativa Oil or Normal Saline Mouthwash; Randomized Controlled Trial

 Ghazala Hassan                 BDS 

 Sarah Ghafoor                    BDS, PhD, MPHE, BSc

 Saira Atif                             BDS, M.Phil, BSc

 Saima Chaudhry                BDS, PhD, MME, BSc

Zubair Ahmed Khan           BDS, MCPS


OBJECTIVES: Chronic periodontitis (CP) is an inflammatory disease of microbial origin that harms the health of the oral
tissues. The objective of this study was to analyze the effects of Nigella sativa oil mouthwash given for two weeks after
non-surgical therapy in patients with CP.
METHODOLOGY: This study was a parallel-arm randomized controlled trial that was conducted after ethical approval and
registered with The trial followed the guidelines of CONSORT and triple blinding was ensured. A total of
fifty voluntary participants, after giving consent and being evaluated for clinical parameters of CP that included Periodontal
Pocket Depth (PPD), CAL (Clinical Attachment Loss), PI (Plaque Index) and BoP (Bleeding on Probing) were divided into a
control group and a treatment group. Both groups underwent scaling and root planning and were given normal saline solution
or Nigella sativa oil respectively to be used as mouthwash daily for two weeks. The clinical parameters were recorded after
two weeks and data was analyzed using SPSS (version 25.0).
RESULTS: It was noted that a statistically significant change was found in the pre-treatment and post-treatment values of all
CP parameters in both the groups after the use of normal saline and Nigella sativa oil mouthwash. No statistically significant
results were obtained when clinical parameters were evaluated between the two groups.
CONCLUSION: The clinical periodontal parameters of PI, CAL, PPD and BoP improved in both study groups two weeks
following non-surgical periodontal therapy irrespective of the Nigella Sativa oil-based mouthwash or normal saline-based
mouthwash used. It is suggested that either both types of mouthwashes had a beneficial effect or sub-gingival ultrasonic
instrumentation itself was enough for improvement of periodontal health irrespective of the mouthwash used.
KEYWORDS: Nigella sativa, Chronic periodontitis, Normal Saline, Oral Health, Dental, Non-surgical Periodontal Therapy
HOW TO CITE: Hassan G, Ghafoor S, Atif S, Chaudhry S, Khan ZA. Non-Surgical periodontal therapy improves clinical
outcomes in patients with chronic periodontitis independent of the use of nigella sativa oil or normal saline mouthwash;
randomized controlled trial. J Pak Dent Assoc 2021;30(2):81-86.
Received: 15 December 2020, Accepted: 31 January 2021

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