Nibrin Double Strand Breakage and its Role in Development of Cancers

Fizza Abidi                                               BDS

Mervyn Hossein                                     FDSRCS(Ed), FDSRCS, FFDRCSI

Saima Akram                                          BSc, BDS, MDS

Angabeen Anjum                                   BDS

The human genetic information has been orchestrated by DNA-damage response pathways. DNA damage response, DNA repair,programmed apoptosis and cell cycle progession are responsible for maintaining the genomic integrity, they initiates the process of tumorigenesis if they are not regulated properly.An article research was done through Google Scholar, Pubmed and
was used for an electronic search of articles, using the following keywords: Double stranded breakage, Nibrin, P95, NBS1.The aim of the review is to point out the impact of double strand breakage and the role of Nibrin in development of cancers. The double strand breakage are pathological insults for all the microorganisms because they can cause the elimination of the essential genetic information, which results in the destruction of DNA replication Nibrin is the first DNA repair gene whose overexpression can promotes the process of tumorigenesis by the activation of phosphoinositol 3 kinase /akt pathways.
KEYWORDS: Nibrin, Double strand breakage, P95, NBS1.
HOW TO CITE: Abidi F, Hossein M, Akram S, Anjum A. Nibrin double strand breakage and its role in development of cancers. J Pak Dent Assoc 2020;29(2):94-99.
Received: 18 April 2019, Accepted: 17 February 2020

Download PDF