Cross Sectional Analysis of Biomarkers In Chronic Periodontitis Patients

M Yousaf1                                                                            PHD                                            

Adil Yousaf2                                                                            BDS

Farheen Khanum3                                                               M.Phil                               

Saleha Gul4                                                                               M.Phil

Saira Gul5                                                                                 DVM                                                                                                  


OBJECTIVE: To compare the serum level of Alkaline Phosphatase, Creatine Phosphokinase and Calcium level in male and female chronic periodontitis patients.

METHODOLOGY: In this study a cross sectional analysis of 40 male and 40 female chronic periodontitis subjects of various age groups, was conducted to assess the associated risk in term of bone loss and cardiovascular diseases by measuring serum Alkaline Phosphatase(ALP), Creatine Phosphokinase(CPK) and Calcium level. Serum Alkaline phosphatase (Normal value: 52-192 U/I) and Creatine phosphokinase (Normal value: 26-171U/I) were determined according to the International Federation of Clinical Chemist (IFCC) recommendations. Calcium ions (Normal value: 8.7-10.4 mg/dL) was determined by Spectrophotometric method Statistical analysis of the acquired data was carried out using SPSS 21.0 software and Microsoft Excel.

RESULTS: A higher mean serum level of ALP in both population group (Male: 195.45 U/I, Female: 203.92 U/I) was observed than normal level (52-192 U/I). The mean value of CPK was observed to be within the normal range for both the groups (Normal: 26-171 U/I) (Male: 143.82 U/I; Female: 122.58 U/I) but was higher for male population than the female population. The mean value of Ca was found to be 10.12 mg/dL for male subjects and 10.28 mg/dL for female subjects (Normal level: 8.7-10.4 mg/dL).

CONCLUSIONS: The results of this study suggest that female subjects are at greater risk of alveolar bone degradation than the male subjects while the higher mean values of serum CPK in male subjects put them at higher risk of cardio vascular disease than the female subjects.

KEY WORDS: Alkaline Phosphatase, Creatine Phosphokinase, Periodontitis, Calcium

HOW TO CITE: Yousaf M, Yousaf A, Khanum F, Gul S, Gul S. Cross sectional analysis of biomarkers in chronic periodontitis patients. J Pak Dent Assoc 2019;28(1):22-26.


Received: 30 July 2018, Accepted: 03 October 2018