Benign Spindel Cell Neoplasam: A Central Myofibroma of Maxilla in Male Child of Seven Years of Age: A Case Report

Hira Nisar1                             BDS
Abul Khair Zalan2                 BDS, MDS
Mehreen Ismail3                    BDS
Sabeen Masood4                  BDS
Ahsan Inayat5                       BDS


Myofibroma is a rare benign spindle cell neoplasm which occurs predominantly in infants and young children. It can occur as
a solitary mass or as a multicentric lesion, consisting of myofibroblasts. In oral cavity, the sites most commonly involved are
the mandible, tongue, lips and buccal mucosa however, it rarely involves the maxilla. It has aggressive clinical presentation
mimicking malignancies. We report a case of a male child seven years of age presented with intraoral swelling on the left palatal
aspect of the maxilla that extended from deciduous upper left second molar to the distal of upper permanent left first molar
causing the mobility of these teeth. Radiologically, the lesion was osteolytic causing marked resorption of alveolar bone and
displacement of permanent maxillary left second molar. A differential diagnosis of peripheral giant cell granuloma, central giant
cell granuloma, fibroma, aggressive fibromatosis, nodular fasciitis, peripheral ossifying fibroma and spindle cell neoplasm was
made. After the excluding malignant and vascular involvement, the surgical excision of the lesion was planned and was carried
out under general anesthesia. Histologically, benign proliferation of spindle cells was seen giving the diagnosis of benign spindle
cell neoplasm. Reports also showed positive immunoreactivity with vimentin and ?SMA while non-responsive to desmin,
validates the diagnosis of myofibroma.
KEYWORDS: spindle cell neoplasm; myofibroma; maxilla
HOW TO CITE: Nisar H, Zalan AK, Ismail M, Masod S, Inayat A. Benign spindel cell neoplasam: a central myofibroma of
maxilla in male child of seven years of age: A case report. J Pak Dent Assoc 2022;31(3):157-160.
Received: 18 August 2021, Accepted: 01 May 2022

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